Article publication date
13 May 2025
ARPANSA review date
25 July 2025
Summary
This systematic review examined the scientific body of evidence for the effect of extremely low frequency electric and magnetic fields (ELF-EMF) exposure on carcinogenesis and co-carcinogenesis in laboratory animals. The review included 13 studies on carcinogenesis and 41 studies on co-carcinogenesis. The review did not conduct a quantitative synthesis of evidence due to large differences in experimental design between studies. Instead, the review provided a narrative overview of the included literature. Included studies were also assessed for their risk of bias (RoB) according to OHAT.
The review found that there is broadly no evidence for a carcinogenic effect from ELF-EMF exposure alone. Results from co-carcinogenesis studies were varied with some reporting statistically significant effects and others reporting none, however, the authors assess that the total weight of evidence is inadequate to make definitive conclusions. It was noted that most studies reporting statistically significant effects utilised exposure magnitudes within the range of 100 to 999 µT. Forty of the included studies were evaluated to be at low RoB and it was noted that studies with higher RoB were more likely to report statistically significant effects. Clear indications of publication bias were also found in the review.
Published in
Environmental Research
Link to study
Carcinogenicity of extremely low-frequency magnetic fields: A systematic review of animal studies
ARPANSA commentary
This review considered cancer endpoints in laboratory animals resulting from ELF-EMF exposure. While the review did not pursue a meta-analysis and thus lacks quantitative results, it does collate a large amount of evidence and provide descriptive statistics which can be used to generate hypotheses. The major shortcoming of this approach is that the review has a notable focus on effect versus no-effect, which has no consideration for effect size or study precision. It is especially important to acknowledge this limitation given that the authors found clear evidence of publication bias among the included studies. This type of bias can have a large impact in binary evidence synthesis methods where statistical significance is the key differentiator between two groups as publication bias can result in an over-representation of statistically significant results in the literature (Thornton, A. & Lee, P., 2000).
The overall conclusion of the review is consistent with the World Health Organization’s assessment of in vivo studies (WHO, 2007) as well as prior reviews (McCann et al., 2000).
ELF-EMF exposure in the general environment arises primarily from electrical supply infrastructure like powerlines, substations, home electrical appliances and wiring. However, it should be noted that the levels encountered in the environment are far below the levels used in most of the studies included by the review and far below the range specified in the review where included studies reported the highest proportion of co-carcinogenic effects. ARPANSA has measured ELF-EMF exposures present in Australian homes and in close proximity to powerlines and substations (Karipidis, K. 2015; Urban, D. et al., 2014). The exposures measured are all far below the international guideline values described by the International Commission on Non-Ionizing Radiation Protection. ARPANSA continues to monitor and review scientific literature related to ELF-EMF exposure and various health endpoints, including cancer. For more information see the ARPANSA factsheet Electricity and Health.
